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About Tramadol

Tramadol is a medication that is used to relieve moderate to severe pain. It is a synthetic opioid analgesic, and it works by binding to the mu-opioid receptor in the brain. Tramadol is available as an immediate-release tablet, an extended-release tablet, and an oral solution.

Tramadol

Tramadol, accessible under the brand name Ultram and others, is an opioid pain medication for treating moderate to severe pain. In a fast-release pill, the onset of pain relief generally begins within an hour when taken by mouth. It is also available by injection. It comes in combination with paracetamol (acetaminophen).

As is common with opioid medications, the most frequent adverse effects include constipation, itching, and nausea. Hallucinations, seizures, an increased risk of serotonin syndrome, drowsiness, and drug addiction are all possible severe side effects. There are concerns that a large amount of quinine may cause jitteriness, sleeplessness, anxiety, and muscle pains in some people. Individuals with kidney or liver issues should contact their doctor if the medicine is being changed. It should not be used by individuals who are at risk of suicide or during pregnancy. Women who are breastfeeding should not take Tramadol, although those who take a single dose should not usually stop nursing. In the liver, tramadol is transformed to O-desmethyltramadol (desmetramadol), an opioid with a stronger affinity for the μ-opioid receptor. Tramadol is a norepinephrine and serotonin reuptake inhibitor (SNRI). 

Tramadol was invented in 1963 and initially marketed as “Tramal” by the West German pharmaceutical firm Grünenthal GmbH in 1977. It was authorized in the United Kingdom and the United States during the mid-1990s. This medication is available in generic form and is marketed under many different brand names worldwide. In 2019, it was one of the most commonly prescribed medications in the United States, with more than 19 million prescriptions filled.

Tramadol, a schedule IV drug in the United States, is most often used to treat moderate to severe pain that is either short- or long-term. There is moderate evidence for usage as a second-line therapy for fibromyalgia, but it isn’t FDA approved for this purpose; nevertheless, the NHS has approved its use as a secondary painkiller. 

In contrast to the general public, who are frequently confused about what an opioid is and how it works, members of the medical community understand that opiate pain medications like tramadol have legitimate therapeutic potential. Tramadol is a synthetic opiate analgesic (narcotic) drug that has been on the market since 1960. It comes in two forms: a long-acting formulation available as tablets (TAPTRA) with advantages over other opiates such as less abuse potential, reduced risk of dependence and addiction, lower incidence of fatal respiratory depression if used for postoperative pain control. The immediate-release version comes in pills; whereas longer-lasting formulations containing additional ingredients exist. -> Tramadol’s analgesic efficacy takes approximately one hour to manifest itself, and 2 to 4 hours to peak after oral administration with an immediate-release formulae. When compared to morphine (thus 100 mg is comparable to 10 mg morphine), tramadol has roughly one tenth the potency (thus 100 mg is commensurate with 10 mg morphine but may vary). It’s nearly equivalent in potency when compared to pethidine and codeine. For moderate pain, its effectiveness is equivalent to codeine at low doses and hydrocodone at high doses; for severe pain, it is less effective than morphine.

The analgesic effects of THC last about 6 hours. The degree of pain relief varies significantly based on a person’s genetics. People with CYP2D6 polymorphisms that lead to reduced desmetramadol formation may not have enough of the active metabolite (desmetramadol) in their systems to effectively manage pain. Tramadol (or other opiate medicines) is occasionally given to restless legs syndrome (RLS) patients who do not respond adequately to first-line therapy, such as dopamine agonists (like pramipexole) or alpha-2-delta (α2δ) ligands. 

Tramadol may not provide adequate pain control for individuals with certain genetic variants of CYP2D6 enzymes as they metabolize tramadol to the inactive molecule. These genetic polymorphisms are not currently routinely tested for in clinical practice.

How to buy Tramadol online?

You can buy tramadol online from a variety of online pharmacies. However, it is important to make sure that you are buying from a reputable source. You can check out reviews of online pharmacies before making your purchase.

 

When you buy tramadol online, you will need to provide a valid prescription. The website will then ask for your shipping information. Once the order is placed, you will typically receive your medication within 5-7 business days.

 

If you have any questions about buying tramadol online, you can contact the customer service department of the website you are ordering from. They will be able to help you with any questions or concerns you may have.

 

Pregnancy and lactation

Tramadol’s use in pregnancy is generally avoided, as it may cause some reversible withdrawal effects in the newborn. A small prospective study in France found, while an increased risk of miscarriages existed, no major malformations were reported in the newborn.Its use during lactation is also generally advised against, but a small trial found that infants breastfed by mothers taking tramadol were exposed to about 2.88% of the dose the mothers were taking. No evidence of this dose harming the newborn was seen.

Labor and delivery

Its use as an analgesic during labor is not advised due to its long onset of action (1 hour). The ratio of the mean concentration of the drug in the fetus compared to that of the mother when it is given intramuscularly for labor pains has been estimated to be 1:94.

Children

Its use in children is generally advised against, although it may be done under the supervision of a specialist. On 21 September 2015, the FDA started investigating the safety of tramadol in use in persons under the age of 17. The investigation was initiated because some of these people have experienced slowed or difficult breathing. The FDA lists age under 12 years old as a contraindication.

Elderly

The risk of opioid-related adverse effects such as respiratory depression, falls, cognitive impairment and sedation is increased. Tramadol may interact with other medications and increase the risk for adverse events.

Liver and kidney failure

The drug should be used with caution in those with liver or kidney failure, due to metabolism in the liver (to the active molecule desmethyltramadol) and elimination by the kidneys.

Dosage of Tramadol

The usual adult dose is 50-100 mg every 4-6 hours as needed for pain relief. The maximum daily dose is 400 mg. Tramadol should be used with caution in people with a history of substance abuse, and it can be habit-forming.

Side effects

Adverse effects from tramadol are similar to those experienced with morphine, and include nausea, dizziness, dry mouth, indigestion, abdominal pain, vertigo, vomiting constipation, drowsiness and headache. These side effects may be more pronounced when the drug is used in combination with other medications.

The main side effects of tramadol are: red colour denotes more serious effects, requiring immediate contact with a health provider.

Dependence and withdrawal

\High doses of tramadol over an extended period of time will lead to physical dependence and withdrawal symptoms. Withdrawal effects include those experienced with both opioids and serotonin-norepinephrine reuptake inhibitors (SNRIs), such as numbness, tingling, paresthesia, and ringing in the ears. Hallucinations, paranoia, intense anxiety, panic attacks, and confusion are all possible psychiatric symptoms. Tramadol withdrawal generally begins 12–20 hours after the final dose and may last up to a week. Withdrawal symptoms from Tramadol typically last longer than other opioids–up to seven days or more of acute withdrawal, as opposed to the typical 3 or 4 days for other codeine analogues.

Overdose

Respiratory depression, addiction, and seizures are all associated with tramadol overdose. Only naloxone partially reverses the harmful effects of tramadol poisoning, increasing the chance of seizure.

In Northern Ireland, tramadol overdoses have occurred and are on the rise; most of these fatalities were caused by other medicines, including alcohol. In 2013, 254 deaths in England and Wales were attributed to tramadol, whereas 379 occurred in Florida in 2011. In 2011, there were 21,649 emergency room visits in the United States that were related to tramadol.

Tramadol can interact with other medications with similar mechanisms of action

Common side-effects

Some common side effects of tramadol include

  • Nausea,
  • Vomiting,
  • Constipation,
  • Dizziness,
  • Headache, and
  • Dry mouth.

Tramadol can also cause drowsiness, so it is important to not drive or operate heavy machinery until you know how the medication affects you.

If you experience any of these side effects, please contact your doctor.

How does Tramadol work?

The analgesic effects of Tramadol are achieved by targeting different receptors on the noradrenergic system, serotonergic system, and opioid receptor systems. Tramadol is a racemic mixture where the positive enantiomer inhibits serotonin reuptake while the negative enantiomer blocks noradrenaline re-uptake. Tramadol has also been shown to release serotonin. Both enantiomers of tramadol act as agonists on the μ-opioid receptor, and its M1 metabolite – O-desmethyltramadol – is an even more potent μ-opioid receptor agonist than tramadol itself. All these effects work together to reduce pain sensation. 

Tramadol has been identified as possessing the following actions:

  • The agonist of the μ-opioid receptor has a significantly higher binding affinity for the MOR than for either the DOR or KOR
  • Because it acts on the serotonin and norepinephrine reuptake systems, it is an SNRI. It binds to 5-HT2C receptors.
  • M1 and M3 muscarinic acetylcholine receptor antagonist
  • α7 nicotinic acetylcholine receptor antagonist
  • NMDA receptor antagonist (very weak)
  • TRPA1 inhibitor.

Tramadol binds to the opioid receptors through its active metabolite desmethyltramadol, which has up to 700-fold greater affinity for the MOR than tramadol. Tramadol itself shows no capacity to activate the MOR in functional activity assays, whereas desmetramadol activates it with high inherent activity (Emax equals that of morphine). Desmetramadol is solely responsible for the opioid effects of tramadol, and it has a far stronger binding affinity to the MOR than tramadol. Both tramadol and desmetramadol have excellent selectivity for the MOR over the DOR and KOR in terms of binding affinity.

 

Interactions of Tramadol with Other Drugs

Tramadol may interact with other medications, so it is important to tell your doctor about all the drugs you are taking, including over-the-counter medications, vitamins, and herbal supplements. Do not start or stop taking any medications without first talking to your doctor.

Some drugs that may interact with tramadol include:

  • Selective serotonin reuptake inhibitors (SSRIs),
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs),
  • Tricyclic antidepressants,
  • MAO inhibitors,
  • Anticholinergics,
  • Antihistamines, and
  • Opioid analgesics.

Tramadol can also increase the levels of certain other medications in your blood, so it is important to have your blood level monitored by your doctor if you are taking tramadol.

If you experience any adverse effects from taking tramadol, please contact your doctor immediately.

 

Risks and Warnings

Tramadol should be used with caution in people with a history of substance abuse, as it can be habit-forming. Tramadol can also interact with other medications, so it is important to tell your doctor about all the medications you are taking, including over-the-counter drugs and supplements.

If you are pregnant or breastfeeding, please consult your doctor before taking tramadol.

Tramadol may not be suitable for everyone, so please talk to your doctor about whether this medication is right for you.

Tramadol can interact with other medications, so it is important to tell your doctor about all the medications you are taking. Tramadol should not be taken with alcohol or other central nervous system depressants. If you have any questions about tramadol, please consult with your healthcare provider.